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Literature summary for 7.2.2.3 extracted from
- Update on the effects of the sodium pump alpha1 subunit on human glioblastoma from the laboratory to the clinic (2018), Expert Opin. Investig. Drugs, 27, 753-763 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bufalin | - |
Homo sapiens |  |
| digoxin | - |
Homo sapiens | |
| hellebrin | - |
Homo sapiens | |
| istaroxime | - |
Homo sapiens | |
| oleandrin | - |
Homo sapiens | |
| Ouabain | shows moderate selectivity (approximately 2.5fold) for alpha1 over alpha2 subunits of the enzyme | Homo sapiens | |
| perillyl alcohol | - |
Homo sapiens | |
| UNBS1450 | specific inhibitor | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | transmembrane protein | Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Na+[side 1] | Homo sapiens | - |
ADP + phosphate + Na+[side 2] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P05023 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| glioblastoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + H2O + Li+[side 1] | - |
Homo sapiens | ADP + phosphate + Li+[side 2] | - |
? | |
| ATP + H2O + Na+[side 1] | - |
Homo sapiens | ADP + phosphate + Na+[side 2] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Na+/K+-ATPase sodium pump | - |
Homo sapiens |
| sodium pump alpha1 subunit | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | expression of the sodium pump alpha1 subunit in glioblastoma tissues is generally higher than that in normal tissues | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the sodium pump alpha1 subunit potentially mediates various antiglioblastoma signaling pathways and affects the sensitivity of glioblastoma cells to drugs | Homo sapiens |
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